C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/00 (2006.01) C07H 21/02 (2006.01) C07K 1/00 (2006.01) C07K 14/81 (2006.01) C07K 16/00 (2006.01) C12P 21/04 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2366689
A bifunctional molecule consisting of a therapeutic molecule and a ligand which specifically binds a transcytotic receptor can be transported specifically from the basolateral surface of epithelial cells to the apical surface. This approach provides the ability to deliver a therapeutic molecule directly to the apical surface of the epithelium, by targeting the transcytotic receptor with an appropriate ligand. Thus, the highest concentration of the therapeutic molecule will be at the apical surface, where it can have the greatest therapeutic effect.
L'invention concerne une molécule bifonctionnelle comportant une molécule thérapeutique et un ligand qui lie spécialement un récepteur transcytotique. En particulier, ladite molécule peut être transportée de la surface basolatérale de cellules épithéliales à la surface apicale. Cette approche offre l'aptitude d'administrer une molécule thérapeutique directement à la surface apicale de l'épithélium, par ciblage du récepteur transcytotique avec un ligand approprié. Ainsi, la concentration la plus forte de la molécule thérapeutique sera à la surface apicale, où elle aura le plus grand effet thérapeutique.
Davis Pamela B.
Eckman Elizabeth
Ferkol Thomas W. Jr.
Case Western Reserve University
Sim & Mcburney
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