C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/335 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2615738
The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built- in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.
L'invention concerne les domaines de l'immunologie et de l'administration de vaccins. Plus précisément, l'invention concerne une technologie d'administration de vaccin bactérien à propriétés immunostimulatoires intégrées permettant d'immobiliser un antigène quelconque étudié, sans modification préalable de l'antigène. L'invention concerne également un complexe d'excipient immunogène chargé d'antigènes comprenant au moins un polypeptide bifonctionnel fixé sur un excipient immunogène, le polypeptide bifonctionnel comprenant un domaine de liaison au peptidoglycane (PBD) par le biais duquel le polypeptide est fixé sur l'excipient, fusionné à un domaine de liaison aux antigènes (ABD) auquel au moins un antigène étudié est lié. L'invention concerne enfin une composition pharmaceutique (par exemple, un vaccin) comprenant un complexe d'excipient immunogène chargé d'antigènes selon l'invention.
Bosma Tjibbe
Leenhouts Cornelis Johannes
Van Roosmalen Maarten Leonardus
Applied Nanosystems B.v.
Fetherstonhaugh & Co.
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