Bifunctional sulfide-containing sulfonamide-chelating agents...

C - Chemistry – Metallurgy – 07 – F

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C07F 13/00 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07B 59/00 (2006.01) C07C 323/67 (2006.01) C07H 21/00 (2006.01) C07K 1/13 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/14 (2006.01) C07K 7/64 (2006.01) C07K 14/475 (2006.01) C07K 14/575 (2006.01)

Patent

CA 2232620

New compounds have the general formula (I): M - L, in which M stands for a radio-isotope of Tc or Re and L stands for a ligand having the general formula (II): B-CR1R2-(CR3R4)n=1,2-S-CHR5-CHR6-SO2-NH-CR7R8-(CR9R10)m=1,2-D, in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 may have various meanings and B and D stand for another group which is suitable for binding metal ions by coordination and for coupling to selectively enriching compounds. Coupling to selectively enriching compounds may alternatively also be mediated by R8. These new compounds are useful for complexing technetium and rhenium and are used for medical diagnosis and therapy.

Ces nouveaux composés répondent à la formule générale (I): M - L, dans laquelle M désigne un radio-isotope de Tc ou de Re et L désigne un ligand qui répond à la formule générale (II): B-CR?1¿R?2¿-(CR?3¿R?4¿)¿n=1,2?-S-CHR?5¿-CHR?6¿-SO¿2?-NH-CR?7¿R?8¿-(CR?9¿R?10¿)¿m=1,2?-D, dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿ et R?10¿ peuvent avoir différentes significations et B et D désignent un groupe additionnel qui sert à la liaison dative des ions métalliques, ainsi qu'à coupler des composés à concentration sélective. Le couplage avec des composés à concentration sélective peut aussi se faire par l'intermédiaire de R?8¿. Ces nouveaux composés servent à former des complexes de technétium et de rhénium et sont utiles en médecine pour le diagnostic et la thérapie.

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