C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 21/00 (2006.01) A61P 21/04 (2006.01) C07K 14/78 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2392046
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
Cette invention se rapporte à des compositions et des procédés servant à traiter, prévenir et diagnostiquer des maladies ou des états associés à un niveau ou une activité anormal de biglycane; à des troubles associés à une membrane cytoplasmique instable, dus par exemple à un complexe de protéines associé à la dystrophine instable (DAPC); à des troubles associés à des synapses ou des jonctions neuromusculaires anormaux, y compris ceux résultant d'une activation de MuSK anormale ou à une agrégation des récepteurs d'acétylcholine (AChR). Parmi ces maladies, on peut citer notamment les dystrophies musculaires, telles que la dystrophie musculaire de Duchenne, la dystrophie musculaire de Becker, les troubles neuromusculaires et les troubles neurologiques.
Amenta Alison
Bowe Mark
Fallon Justin
Hagiwara Hiroki
Mckechnie Beth
Borden Ladner Gervais Llp
Brown University Research Foundation
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