Bilayer pharmaceutical tablet comprising telmisartan and a...

Details Bilayer pharmaceutical tablet comprising telmisartan and a... Bilayer pharmaceutical tablet comprising telmisartan and a...

A - Human Necessities

61

K

A61K 31/549 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 31/4184 (2006.01)

Patent

CA 2472392

A bilayer pharmaceutical tablet comprises a first layer formulated for immediate release of the angiotensin II receptor antagonist telmisartan from a dissolving tablet matrix which contains telmisartan in substantially amorphous form, and a second layer formulated for immediate release of a diuretic like hydrochlorothiazide from a fast disintegrating tablet matrix. A method of producing the bilayer tablet is also disclosed.

L'invention concerne un comprimé pharmaceutique bicouche comprenant une première couche formulée pour la libération immédiate de l'antagoniste du récepteur de l'angiotensine II, appelé telmisartan, à partir d'une matrice de comprimé destinée à se dissoudre qui contient le telmisartan sous forme sensiblement amorphe, et une seconde couche formulée pour la libération immédiate d'un hydrochlorothiazide du type diurétique à partir d'une matrice de comprimé à désintégration rapide. L'invention concerne également une méthode de production dudit comprimé bicouche.

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