Bile acid derivatives, process for their preparation and use...

Details Bile acid derivatives, process for their preparation and use... Bile acid derivatives, process for their preparation and use...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/56 (2006.01) C07J 9/00 (2006.01) C07J 31/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2057099

Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals The invention relates to bile acid derivatives of the formula I G1 - X - G2 (I) in which G1 and G2 are bile acid radicals or modified bile acid radicals in the form of the free acids, the esters or amides, the salt forms and also the forms derivatized on the alcohol groups and X is a bridge group or a single covalent bond, it being possible for G1 and G2 to be optionally bonded via X. The compounds according to the invention have a high affinity for the specific bile acid transport system of the small intestine and inhibit bile acid absorption in a concentration-dependent and competitive manner.

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