Bile acids and biguanides as protease inhibitors for...

A - Human Necessities – 61 – K

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Details

A61K 31/575 (2006.01) A61K 31/155 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2740477

This invention relates to methods of preserving the integrity of peptides in the gut. In particular it concerns the use of certain compounds as inhibitors of gut proteases. Compounds identified as having gut protease inhibitory activity are biguanides, certain bile acids and pharmaceutically acceptable salts of these compounds. This activity makes these compounds useful for co-administration with prophylactic or therapeutic peptides. This invention relates to methods of inhibiting gut proteases and peptide formulations comprising these gut protease inhibitor.

Cette invention a pour objet des méthodes visant à préserver lintégrité de peptides dans lintestin. En particulier, elle concerne lutilisation de certains composés en tant quinhibiteurs des protéases intestinales. Les composés identifiés comme possédant une activité inhibitrice des protéases intestinales sont des biguanides, certains acides biliaires et des sels pharmaceutiquement acceptables de ces composés. Cette activité rend ces composés utiles pour une coadministration avec des peptides prophylactiques ou thérapeutiques. Cette invention a pour objet des méthodes dinhibition des protéases intestinales et des formulations peptidiques renfermant ces inhibiteurs de protéases intestinales.

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