Bilobalide derivatives, their applications and formulations...

Details Bilobalide derivatives, their applications and formulations... Bilobalide derivatives, their applications and formulations...

C - Chemistry, Metallurgy

07

F

167/245, 167/310

C07F 9/655 (2006.01) A61K 9/127 (2006.01) A61K 31/34 (2006.01) C07D 493/20 (2006.01) C07F 9/10 (2006.01)

Patent

CA 2035951

Complexes between natural or synthetic phospho- lipids and bilobalide, a sesquiterpene extracted from the leaves of Gingko biloba, are disclosed, as well as the preparation thereof and their therapeutic application as antiinflammatory agents and as agents for the treatment of disorders associated with inflammatory or traumatic neuritic processes. These new compounds, which exhibit a different bioavailability compared with free bilobalide, are suitable for incorporation into pharmaceutical formulations for systemic and topical administration: the latter route has been found to be particularly useful for the treatment of common peripheral disorders associated with inflammatory or neurodystrophic alterations.

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