Bimodal chromatographic resolving zone

Details Bimodal chromatographic resolving zone Bimodal chromatographic resolving zone

B - Operations, Transporting

01

D

252/18, 73/93

B01D 15/08 (2006.01) B01J 20/28 (2006.01) B01J 20/32 (2006.01) G01N 30/52 (2006.01)

Patent

CA 1101827

ABSTRACT OF THE DISCLOSURE Disclosed herein is a resolving zone for a chromatograph comprising a plurality of porous, silica macroparticles chosen to provide the resolving zone with a bimodal pore distribution, the average pore size for each mode being such that the linear portions of the molecular weight calibration curve for each pore size in the bimodal distribution are nonoverlapping and the pore volume of each mode being such that the aforesaid linear portions are substantially parallel. The macro- particles can be either totally or superficially porous. The resolving zone can be composed of either a plurality of macroparticles each having a bimodal pore distribution or a plurality of macroparticles having one pore size distribution and a plurality of macroparticles having another pore distribution.

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