Bimodal molecular weight hyaluronate formulations and...

A - Human Necessities – 61 – K

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A61K 31/715 (2006.01) A61K 9/00 (2006.01) A61K 31/73 (1990.01)

Patent

CA 2129238

2129238 9315744 PCTABS00024 Compositions and methods useful for protecting human or animal eye cell layers and tissues exposed to trauma, e.g., during surgery, are disclosed. In one embodiment, the method comprises administering a protective amount of an ophthalmically acceptable aqueous composition containing a first alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of at least about 300,000, for example, in the range of about 500,000 to about 750,000, and a second alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of less than about 200,000, for example, in the range of about 25,000 to about 175,000, to eye cell layers and tissues prior to the exposure to the trauma.

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