Binding agents and their use in targeting tumor cells

Details Binding agents and their use in targeting tumor cells Binding agents and their use in targeting tumor cells

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 45/06 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2481796

The present invention concerns methods and compositions for administering a binding agent to a patient wherein the patient generates a response to autologous tumor. The binding agents target apoptotic tumor cells and facilitates the uptake of these apoptotic tumor cell are taken up by dendritic cells or other antigen presenting cells for processing and presentation to the immune system without the expression of circulating tumor-associated antigen (or without the need of circulating tumor antigen).

La présente invention concerne des méthodes et des compositions d'administration d'un agent de liaison à un patient qui va générer une réponse à la tumeur autologue. Les agents de liaison ciblent les cellules tumorales apoptotiques et facilitent le captage de ces cellules tumorales apoptotiques captées par des cellules dendritiques ou d'autres cellules présentant un antigène pour le traitement et la présentation au système immunitaire sans expression d'un antigène associé à la tumeur de circulation (ou sans avoir à recourir à l'antigène associé à la tumeur de circulation).

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