C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61P 29/00 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2709411
The present invention relates to an antibody or antigen-binding fragment, or a variant, fusion or derivative thereof, for use in medicine, wherein the antibody or antigen-binding fragment, variant, fusion or derivative thereof has binding specificity for an integrin .alpha.1 1 subunit, or a heterodimer thereof. In particular, the invention relates to the use of such antibodies or antigen-binding fragments, variants, fusions or derivatives thereof, in the treatment of inflammatory disorders such as arthritic diseases (e.g. RA and OA).
L'invention porte sur un anticorps ou l'un de ses fragment sde fixation à un antigène, ou l'une de ses variantesou fusions ou l'un de ses dérivés, à usage médical, lesquels présentent une spécificité de fixation pour la sous-unité a-11 de l'intégrine ou l'un de ses hétérodimères. L'invention porte particulièrement sur l'utilisation de tels anticorps ou fragments etc. pour le traitement de troubles inflammatoires tels que l'arthrite (par exemple l'arthrite rhumatoïde et l'ostéoarthrite).
Cartela R&d Ab
Gowling Lafleur Henderson Llp
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