C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 38/08 (2006.01) A61K 47/48 (2006.01) A61P 21/00 (2006.01) C07K 7/06 (2006.01) C07K 14/475 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2510893
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therepeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and other metabolic disorders including diabetes and obesity.
L'invention concerne des agents de liaison comprenant des peptides capables de se lier à la myostatine et d'en inhiber l'activité. Selon une variante, l'agent de liaison comprend au moins un peptide de liaison avec la myostatine fixé directement ou indirectement au moins à un véhicule du type polymère ou domaine Fc. On a constaté que les agents de liaison considérés augmentaient la masse musculaire maigre, en administration aux animaux, et faisaient descendre le taux de masse adipeuse au taux de muscle. L'invention concerne également des compositions thérapeutiques qui renferment ces agents et qui sont utiles pour le traitement des troubles d'atrophie musculaire et autres troubles du métabolisme.
Boone Thomas Charles
Han Hq
Min Hosung
Amgen Inc.
Smart & Biggar
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