G - Physics
01
N
G01N 33/68 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2294120
The present invention relates to binding members that are capable of binding to and effecting the function of proteins useful in facilitating folding of large polypeptides. The present invention particularly relates to the chaperone CCT. The invention provides materials and methods for effecting the biological activity of CCT within the cell so as to prevent the folding to CCT substrates such as actin, tubulin or cyclin. The inventors provide specific binding members capable of occupying a CCT substrate binding site thereby preventing the substrate from binding. Further, the present invention provides methods for screening for such binding members which effect the biological activity of CCT.
La présente invention concerne des éléments de liaison susceptibles de se fixer sur des protéines, et de déclencher la fonction de protéines, qui facilite le repliement de grands polypeptides. La présente invention concerne en particulier la chaperone CCT. L'invention a trait à des matières et procédés permettant de déclencher l'activité biologique de la CCT à l'intérieur de la cellule et ce, afin d'empêcher le repliement des chaînes sur les substrats de CCT tels que l'actine, la tubuline ou la cycline. L'invention concerne également des éléments de liaison spécifiques, susceptibles d'occuper un site de fixation du substrat de CCT et donc d'empêcher la fixation du substrat. L'invention concerne enfin des procédés permettant de cribler de tels éléments de liaison qui déclenchent l'activité biologique de la CCT.
Hynes Gillian
Liou Anthony Kian-Fong
Willison Keith
Bereskin & Parr
The Institute Of Cancer Research: Royal Cancer Hospital
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