Binding domain-immunoglobulin fusion proteins

Details Binding domain-immunoglobulin fusion proteins Binding domain-immunoglobulin fusion proteins

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/44 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2433877

The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as monomeric polypeptides. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including immunotherapeutic applications.

L'invention concerne de nouvelles protéines de fusion d'immunoglobuline de domaine de liaison qui comprennent un domaine de liaison pour une structure de même origine telle qu'un antigène, un contre-récepteur ou similaire, un polypeptide à région charnière qui a entre 0 et 1 résidu de cystéine, et les domaines d'immunoglobulines CH2 et CH3; ils sont capables d'ADCC et/ou CDC et existent principalement sous forme de polypeptides monomères. Les protéines de fusion peuvent être fabriquées par recombinaison avec des taux d'expression élevés. L'invention concerne également des compositions et procédés correspondants, y compris des applications immunothérapeutiques.

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