C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/015 (2006.01) C07K 14/445 (2006.01) C12N 5/10 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2171193
The present invention provides isolated polypeptides useful in the treatment and prevention of malaria caused by Plasmodium falciparum or P.vivax. In particular, the polypeptides are derived from the binding domains of the proteins in the EBL family as well as the sialic acid binding protein (SABP) on P.falciparum merozoites. The polypeptides may also be derived from the Duffy antigen binding protein (DABP) on P.vivax merozoites.
L'invention concerne des polypeptides isolés utiles dans le traitement et la prévention du paludisme causé par plasmodium falciparum ou P. vivax. Plus particulièrement, ces polypeptides dérivent des domaines de liaison des protéines de la famille EBL (ligand de liaison de l'érythrocyte) ainsi que de la protéine de liaison à l'acide sialique (SABP) située sur les mérozoïtes de P. falciparum. Ces polypeptides peuvent aussi provenir de la protéine de liaison à l'antigène de Duffy (DABP) située sur les mérozoïtes de P. vivax.
Chitnis Chetan
Miller Louis H.
Peterson David S.
Sim Kim Lee
Su Xin-Zhuan
Department Of Health And Human Services (the)
Fetherstonhaugh & Co.
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