Binding domains in notch and delta proteins

Details Binding domains in notch and delta proteins Binding domains in notch and delta proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2102208

The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The in- vention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporyth- mic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Topor- ythmic genes, as used herein, refers to the genes Notch, Delta and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Antibodies to human Notch and to adhesive fragments are addi- tionally provided.

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