Binding domains of proteins of the repulsive guidance...

Details Binding domains of proteins of the repulsive guidance... Binding domains of proteins of the repulsive guidance...

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2624562

The invention concerns the identification and use of neogenin receptor-binding domains of members of the repulsive guidance molecule (RGM) protein family as well as polypeptide fragments derived therefrom. The inventive domains, i.e. peptide fragments are suited as agents for the active or passive immunization of individuals as well as diagnostic and therapeutic agents for use with diseases or pathological conditions in whose origin or progression, a member of the RGM family and a cellular receptor assigned to this molecule are involved. The invention also concerns monoclonal and polyclonal antibodies directed against the inventive binding domains and against the polypeptides derived therefrom, and to method for producing the inventive domains, polypeptides and antibodies.

L'invention concerne l'identification et l'utilisation des domaines liant le récepteur néogénine de membres de la famille protéinique des molécules de guidage répulsif (RGM) ainsi que des fragments de polypeptides en dérivant. Ces domaines et ces fragments de polypeptides peuvent servir d'agents pour l'immunisation active ou passive d'individus et d'agents de diagnostic et de thérapie à utiliser dans le cas de maladies ou d'états à la genèse et à l'évolution desquels participent un membre de la famille RGM et un récepteur cellulaire associé à cette molécule. La présente invention porte également sur des anticorps monoclonaux et polyclonaux agissant contre les domaines de liaison de l'invention et contre les polypeptides en dérivant, ainsi que sur des procédés pour produire lesdits domaines, polypeptides et anticorps.

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