Binding ligand linked drug delivery conjugates of tubulysins

Details Binding ligand linked drug delivery conjugates of tubulysins Binding ligand linked drug delivery conjugates of tubulysins

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2680535

Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands. The conjugates also include a releasable bivalent linker.

L'invention concerne des composés, compositions pharmaceutiques et procédés pour traiter des populations de cellules pathogènes. Les composés décrits ici comprennent des composés de tubulysines et des ligands de liaison à un récepteur de vitamine. Les conjugués comprennent également un liant bivalent pouvant être libéré.

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