Binding member towards pneumolysin

Details Binding member towards pneumolysin Binding member towards pneumolysin

C - Chemistry, Metallurgy

07

K

C07K 16/12 (2006.01) A61K 39/09 (2006.01) A61K 39/40 (2006.01) A61P 31/00 (2006.01) C07K 14/315 (2006.01) C07K 16/46 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) C12N 15/79 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2578361

The present invention relates to an anti-haemolytic binding member comprising at least one binding domain capable of specifically binding Pneumolysin, in particular to a binding member having at least two biding domains, to the use of said binding members in diagnostic methods as well as for treatment. In a preferred embodiment the binding member is an antibody, such as a human antibody, or a fragment thereof, and it may also be a bispecific antibody.

Cette invention concerne un élément de liaison antihémolytique comprenant au moins un domaine de liaison capable de se lier spécifiquement à la Pneumolysine, plus particulièrement, un élément de liaison présentant au moins deux domaines de liaison. L'invention concerne également l'utilisation de ces éléments de liaison dans des méthodes diagnostiques ainsi que dans des méthodes thérapeutiques. Dans un mode de réalisation privilégié, l'élément de liaison est un anticorps, tels qu'un anticorps humain, ou un fragment de celui-ci, et il peut également être un anticorps bispecifique.

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