Binding moieties for fibrin

Details Binding moieties for fibrin Binding moieties for fibrin

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 38/04 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01) C07K 5/00 (2006.01) C07K 5/107 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/56 (2006.01) C07K 7/64 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 15/00 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2376245

The present invention provides binding moieties for fibrin, which have a variety of uses wherever detecting, isolating or localizing fibrin, and particularly fibrin as opposed to fibrinogen, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding fibrin and recognizing the form of polymerized fibrin found in thrombi. Such polypeptides and disclosed derivatives are useful, e.g., as imaging agents for thrombi. Preferred embodiments useful as magnetic resonance imaging (MRI) contrast agents useful for detecting a thrombus <i>in vivo</i> are also disclosed.

La présente invention concerne des fractions se liant à la fibrine, qui comportent diverses applications, notamment dans la détection, l'isolement ou la localisation de la fibrine ; la détection, l'isolement ou la localisation de la fibrine par opposition au fibrinogène est particulièrement avantageuse. L'invention concerne en particulier des polypeptides de synthèse isolés, capables de se lier à la fibrine et de reconnaître la forme de fibrine polymérisée présente dans les thrombus. Ces polypeptides et dérivés décrits sont utiles, par exemple, comme agents d'imagerie de thrombus. Des formes de réalisation préférées, utiles comme agents de contraste dans l'imagerie par résonance magnétique (IRM) pour détecter un thrombus <i>in vivo,</i> sont également décrites.

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