Binding molecules with multiple binding sites, compositions...

Details Binding molecules with multiple binding sites, compositions... Binding molecules with multiple binding sites, compositions...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 15/13 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2698419

The present invention relates to binding molecules, such as amino acid sequences with multiple antigen binding sites. In particular, the binding molecules of the present invention have at least two antigen binding sites that partially or fully overlap with each other and that are directed against at least two different naturally occurring binding molecules. The invention further relates to uses of such binders, for example in methods for inhibiting and/or blocking of the interaction between said at least two naturally occurring binding molecules and a third naturally occurring binding molecule.

Cette invention concerne des molécules de liaison, telles que des séquences d'acides aminés comprenant plusieurs sites de liaison à l'antigène. Plus particulièrement, les molécules de liaison décrites dans cette invention présentent au moins deux sites de liaison à l'antigène qui se chevauchent totalement ou en partie et qui sont dirigés contre au moins deux différentes molécules de liaison d'origine naturelle. Cette invention concerne les utilisations de tels liants, par exemple, dans des méthodes consistant à inhiber et/ou à bloquer l'interaction entre ces molécules d'origine naturelle et une troisième molécule d'origine naturelle.

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