Binding of e-selectin, p-selectin or l-selectin to...

Details Binding of e-selectin, p-selectin or l-selectin to... Binding of e-selectin, p-selectin or l-selectin to...

C - Chemistry, Metallurgy

07

H

C07H 15/20 (2006.01) A61K 31/70 (2006.01) C07H 15/18 (2006.01) C07H 15/203 (2006.01)

Patent

CA 2189013

This invention relates to compounds having general structure (II) that inhibit the binding of E-selectin and/or P-selectin to sialyl-Lewisx or sialyl-Lewisa presented on a cell surface. This invention also relates to methods of inhibiting the binding of E-selectin and/or P-selectin to sialyl-Lewisx or sialyl-Lewisa presented on a cell surface using said compounds, and to pharmaceutically active compositions comprising compounds that inhibit the binding of E-selectin to sialyl-Lewisx. This invention also concerns methods of using said compounds for treatment of septic shock, ARDS, Crohn's disease, chronic inflammatory disease such as psoriasis and rheumatoid arthritis, and reperfusion injuries that occur following heart attacks, strokes and organ transplants.

L'invention porte sur des composés de structure générale (II) inhibant la fixation de la E-sélectine et/ou de la P-sélectine sur la sialyl-Lewis-?x¿ ou la sialyl-Lewis-?a¿ présente à la surface d'une cellule. Elle porte également sur des méthodes d'inhibition de la fixation de la E-sélectine et/ou de la P-sélectine sur la sialyl-Lewis-?x¿ ou la sialyl-Lewis-?a¿ présente à la surface d'une cellule à l'aide desdits composés et sur des compositions pharmaceutiques comprenant des composés inhibant la fixation de la E-sélectine sur la sialyl-Lewis-?x¿. Elle porte en outre sur des méthodes d'emploi desdits composés pour le traitement de chocs septiques, de l'ARDS, de la maladie de Crohn, des troubles inflammatoires chroniques tels que le psoriasis ou l'arthrite rhumatoïde, et les traumatismes de reperfusion consécutifs à des arrêts cardiaques, à des attaques ou à des transplantations d'organes.

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