Binding of growth hormone to liposomes

Details Binding of growth hormone to liposomes Binding of growth hormone to liposomes

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 38/25 (2006.01)

Patent

CA 2079443

Crosslinking reagents glutaraldehyde and ethylene glycol diglycidyl ether have been used to bind epidermal growth factor ("EGF") to liposomal surfaces without utilizing the disulfide bridge linkage of EGF and, therefore, not adversely affecting the functionality of EGF. The crosslinking occurs through the amine residues offered by EGF and liposomes having phosphatidy- lethanolamine. The resulting EGF-modified liposomes offer potential as a microscopic drug delivery system.

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