Binding of immune complexes by modified forms of c-reactive...

Details Binding of immune complexes by modified forms of c-reactive... Binding of immune complexes by modified forms of c-reactive...

C - Chemistry, Metallurgy

07

K

167/129, 167/44,

C07K 16/18 (2006.01) A61M 1/36 (2006.01) C07K 1/22 (2006.01) C07K 16/06 (2006.01) G01N 33/543 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01)

Patent

CA 1339290

A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with modified forms of C-reactive protein. The method may be employed for diagnostic and therapeutic purposes and to deplete fluids of aggregated immunoglobulin or immune complexes. Further, a method of reducing the levels of immune complexes in a mammal comprising administering modified-CRP to the mammal, and a method of binding immunoglobulins comprising contacting them with modified C-reactive protein. Also, a method of binding aggregated immunoglobulin or immune complexes comprising contacting them with antibody to neo-CRP, and a method of modifying C-reactive protein. Finally, a test kit for detecting or quantitating immune complexes and a device for removing aggregated immunoglobulin or immune complexes from fluids are disclosed.

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