Binding of pathological forms of proteins using conjugated...

Details Binding of pathological forms of proteins using conjugated... Binding of pathological forms of proteins using conjugated...

C - Chemistry, Metallurgy

07

K

C07K 1/22 (2006.01) A61K 31/795 (2006.01) C08G 61/12 (2006.01)

Patent

CA 2721770

The invention relates to a method for separation of an aggregated misfolded protein from an environment comprising a non-aggregating normal form of the protein, comprising contacting both said misfolded and normal protein with a conjugated polyelectrolyte (CPE) and separating the CPE/protein complex from the other constituents of the sample.

L'invention concerne un procédé destiné à séparer une protéine mal repliée agrégée d'un environnement comprenant une forme normale non agrégante de la protéine, consistant à mettre ladite protéine mal repliée et ladite protéine normale en contact avec un polyélectrolyte conjugué (CPE), et à séparer le complexe CPE/protéine des autres constituants de l'échantillon.

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