Binding of recognizing substances to liposomes

Details Binding of recognizing substances to liposomes Binding of recognizing substances to liposomes

A - Human Necessities

61

K

A61K 9/127 (2006.01)

Patent

CA 2079444

Methodologies have been developed and certain recognizing substances and crosslinking reagents have been identified to modify liposomes. Crosslinking reagents link residues on the liposomal surface to the residues offered by certain recognizing sub- stances: The crosslinking reagents include glutaraldehyde (GAD) and a water soluble carbodiimide, preferably, 1-ethyl-3-(3-di- methylaminopropyl) carbodiimide (EDC). The recognizing substances include gelatin, collagen, and hyaluronic acid (HA). Fol- towing these methodologies; recognizing substances can be utilized as an adhesive or glue to attach the liposomes onto a target area: These"bioadhesive" liposomes offer potential advantages as a microscopic drug delivery system.

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