Binding peptides having a c-terminally disposed specific...

Details Binding peptides having a c-terminally disposed specific... Binding peptides having a c-terminally disposed specific...

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2691819

Specific binding peptides having a general schematized structure of an optional N-terminal hinge region joined to an immunoglobulin-derived constant sub-region comprising a CH2 region and a CH3 region, followed by a PIMS linker peptide and at least one specific binding domain are provided, along with encoding nucleic acids, vectors and host cells. Also provided are methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.

L'invention concerne des peptides de liaison présentant une structure générale schématisée d'une région charnière N-terminal optionnelle reliée à une sous-région constante dérivée d'une immunoglobuline comprenant une région CH2 et une région CH3, suivie par un peptide de liaison PIMS et au moins un domaine de liaison spécifique, ainsi que des acides nucléiques, des vecteurs et des cellules hôtes de codage. L'invention concerne également des méthodes de fabrication desdits peptides et des méthodes d'utilisation desdits peptides pour traiter ou prévenir diverses maladies, troubles ou états pathologiques, ainsi que pour améliorer au moins un symptôme associé à ces maladies, troubles ou états pathologiques.

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