Binding polypeptides and uses thereof

Details Binding polypeptides and uses thereof Binding polypeptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/32 (2006.01) C40B 30/04 (2006.01) C40B 40/08 (2006.01)

Patent

CA 2631327

The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/ or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. In addition, compositions and methods of use for treatment of cancer and immune related conditions are provided.

L'invention concerne des anticorps ou des fragments de liaison antigénique de ces anticorps dirigés contre le DR5 et le HER-2. Les anticorps et/ou les fragments de liaison antigénique de ces anticorps comprennent des régions CDR variantes qui présentent une diversité de séquence d'acides aminés fortement restreinte. L'invention concerne également ces polypeptides sous la forme de polypeptides de fusion à des polypeptides hétérologues tels qu'au moins une partie de phage ou de protéines d'enveloppe virale, des marqueurs et des segments de liaison. Elle concerne en outre des compositions et leurs procédés d'utilisation pour le traitement de cancer et de conditions immunitaires apparentées.

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