Binding polypeptides with optimized scaffolds

Details Binding polypeptides with optimized scaffolds Binding polypeptides with optimized scaffolds

C - Chemistry, Metallurgy

07

K

C07K 16/32 (2006.01)

Patent

CA 2651567

The invention provides variant heavy chain variable domains (VH) with increased folding stability. Libraries comprising a plurality of these polypeptides are also provided. In addition, compositions and methods of generating and using these polypeptides and libraries are provided.

L'invention concerne des domaines variables à chaîne lourde de variant (VH) à stabilité de repli accrue. De plus, cette invention concerne des bibliothèques renfermant une pluralité de ces polypeptides. Sont en outre décrites des compositions et des méthodes permettant de générer et d'utiliser ces polypeptides et bibliothèques.

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