Binding proteins specific for insulin-like growth factors...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) C07K 16/22 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2633956

Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Image

La présente invention concerne des protéines de liaison telles que des anticorps dirigés contre l'IGF-II et présentant une réactivité croisée vis-à-vis de l'IGF-I et les utilisations de tels anticorps. L'invention concerne en particulier des anticorps monoclonaux entièrement humains dirigés contre l'IGF-II et présentant une réactivité croisée vis-à-vis de l'IGF-I. L'invention concerne en outre des séquences nucléotidiques codant pour des molécules d'immunoglobuline à chaînes lourdes et légères et des séquences d'acides aminés comprenant ces molécules, en particulier des séquences correspondant à des séquences de chaînes lourdes et légères contiguës couvrant les régions charpente et/ou les régions déterminant la complémentarité (CDR), spécifiquement de FR1 jusqu'à FR4 ou de CDR1 jusqu'à CDR3.

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