Binding structures directed against the ca55.1 antigen

Details Binding structures directed against the ca55.1 antigen Binding structures directed against the ca55.1 antigen

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/20 (2006.01) G01N 33/563 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2174972

Antibodies which recognise a tumour related amtigen designated CA55.1 such as hybridoma 55.1 deposited as ECACC deposit No. 93081901 in which the complementary determining regions have the following sequences: a) heavy chain: CDR1: G Y W I H (SEQ ID N0:27);CDR2: E V N P S T G R S D Y N E K F K N(SEQ ID NO:28);CDR3: E R A Y G Y D D A M D Y(SEQ ID NO:29);b) light chain: CDR1: K S S Q S L L N S R T R K N Y L A (SEQ ID NO: 30);CDR2: W A S T R T S (SEQ ID NO: 31); CDR3: K Q S Y T L R T (SEQ ID NO: 32); or a conservative analogue thereof. The peptide ACEHRGSGWC (SEQ ID NO: 26), as displayed on the surface of bacteriophage NCIMB No. 40638, is a mimic of the tumor related amtigen CA55.1.

On décrit des anticorps, qui reconnaissent un antigène lié à une tumeur et désigné CA55.1, tel que l'hybridome 55.1 déposé sous le numéro de dépôt ECACC 93081901, où les régions déterminantes de complémentarité présentent les séquences suivantes: a) chaîne lourde: CDR1: G Y W I H (identification de séquence numéro 27); CDR2: E V N P S T G R S D Y N E K F K N (identification de séquence numéro 28); CDR3: E R A Y G Y D D A M D Y (identification de séquence numéro 29); b) chaîne légère: CDR1: K S S Q S L L N S R T R K N Y L A (identification de séquence numéro 30); CDR2: W A S T R T S (identification de séquence numéro 31); CDR3: K Q S Y T L R T (identification de séquence numéro 32); ou bien on décrit un de leurs analogues conservateurs. Le peptide ACEHRGSGWC (identification de séquence numéro 26), tel qu'exposé à la surface du bactériophage NCIMB no. 40638, constitue un mimétique de l'antigène lié à une tumeur désigné CA55.1.

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