Bio-energy muscle relaxants

Details Bio-energy muscle relaxants Bio-energy muscle relaxants

A - Human Necessities

61

K

A61K 31/15 (2006.01) A61P 21/02 (2006.01)

Patent

CA 2333844

Differences of physiology functions of the human muscle tissues are mainly determined by their own initiation and signal transmission systems, defined as pre-muscle molecular motor mechanism. However, at molecule level, mechanism of the muscle molecular motor is the same in all kinds of muscle tissues. The current medications, drugs, and therapies for diseases and symptoms related to abnormal muscle contraction are aimed just at the pre-muscle molecular motor mechanism, whereas without intending to effect on the muscle molecular motor mechanism at all. The muscle molecular motor mechanism mainly involves recycling of actin-myosin filament cross- bridge and sliding movement. In the process, bio-energy provided by ATP hydrolysis is necessarily required. Therefore, abnormal muscle contraction under diseased conditions may be modified by inhibition of the muscle molecular motor with the actin-myosin ATPase inhibitor, which blocks hydrolysis of ATP, then reduces release of bio-energy for the muscle contraction, so called as bio-energy muscle relaxants.

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