Bio-membrane for tissue regeneration

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/00 (2006.01) A61F 2/02 (2006.01) A61L 24/04 (2006.01) A61L 24/10 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2653546

A bio-membrane with angiogenic activity for implant in 'tissue regeneration and repair, including bone reconstruction and the repair of skin and soft tissue lesions is described, essentially constituted by a gel able to provide support and growth and/or differentiation and/or angiogenic factors for the full in vivo functionality of the cell, containing also mesenchymal stem/precursor cells, an implant device for reconstructive surgery of bone tissue, of skin and soft tissue lesions which comprises the bio-membrane, and a method for its obtainment. Use of the gel alone for tissue regeneration and of adhesive plasters that comprise it is also described.

La présente invention concerne une biomembrane à activité angiogène destinée à être implantée dans le cadre de la régénération et de la réparation des tissus, notamment pour la reconstruction osseuse et la réparation de lésions touchant la peau et les parties molles. La membrane de l'invention est essentiellement constituée d'un gel capable d'apporter un soutien et des facteurs de croissance et/ou de différenciation et/ou angiogènes à l'ensemble des fonctionnalités in vivo de la cellule ; elle contient également des cellules précurseurs/souches mésenchymateuses. L'invention concerne un dispositif implantable pour la chirurgie de reconstruction du tissu osseux, des lésions de la peau et des parties molles comprenant ladite biomembrane, ainsi qu'un procédé pour le fabriquer. L'invention concerne enfin l'utilisation du gel seul pour la régénération tissulaire ainsi que des pansements adhésifs le comprenant.

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