G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/544 (2006.01) C07K 17/02 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2098960
The biologically recognising layer on a solid phase consists of biologically recognising molecules comprising regions which recognise (bond) the substance to be analysed and regions which do not recognise (do not bond) the substance to be analysed. The biologically recognising molecules are aligned on a suitably modified surface by means of molecular regions which do not recognise the substance to be analysed. The biologically recognising molecules are cross-linked with the aligning surface and are consequently covalently altered. The molecular regions recognising the substance to be analysed are not altered by the covalent bonding and retain their bonding activity. The layer is produced in a novel two-stage method. In the first step, the biologically recognising molecules, the aligning molecules and the carrier molecules are adsorbed. In the second step the molecules are covalently anchored by cross-linking. Cross-linking is brought about by photolytic activation of the reagent bonded to the carrier molecules. Even after reacting with the earner molecules the reagent contains water-solubilising groups.
Barner Richard
Huber Walter
Hubscher Josef
Hurst Jurg
Schlatter Daniel
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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