Bio-spectral imaging system and methods for diagnosing cell...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01) A61B 6/00 (2006.01) A61B 10/00 (2006.01) A61K 49/00 (2006.01) A61N 5/10 (2006.01) G01J 3/28 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2483420

A bio-spectral imaging system and methods for in situ diagnosis of a disease state in biological tissue or cells of a living organism are provided. In one form, a method includes applying to the tissue or cells in situ a biological stain composition that includes at least one metachromatic dye; performing a spectral analysis to obtain at least one spectrum of the stained tissue or cells; comparing the spectrum with spectra from a library of spectra of similarly stained reference tissue or cells that have been categorized as diseased or non-diseased; and correlating the spectrum to a disease state. The system and methods may be used to diagnose, for example, pre-cancer and/or cancer, as well as diseases caused by various microorganisms. Methods for creating a library of spectra, methods for monitoring the efficiency of photodynamic therapy of diseased biological tissue or cells in vivo, as well as methods for improving the efficiency of photodynamic therapy are also provided.

La présente invention concerne un système et des méthodes d'imagerie de spectres biologiques permettant de diagnostiquer in situ une maladie dans un tissu biologique ou dans des cellules d'un organisme vivant. Dans un mode de réalisation, l'invention concerne une méthode consistant à appliquer sur le tissu ou sur les cellules in situ une composition de coloration biologique qui comprend au moins un colorant métachromatique ; à mettre en oeuvre une analyse spectrale afin d'obtenir au moins un spectre du tissu ou des cellules colorés; à comparer le spectre avec des spectres d'une bibliothèque de spectres d'un tissu ou de cellules de référence de coloration semblable qui ont été catégorisés en tant que malades ou non malades; et à corréler le spectre avec une maladie. Ledit système et lesdites méthodes peuvent être utilisés pour diagnostiquer, par exemple, le pré-cancer et/ou le cancer, ainsi que des maladies induites par divers microorganismes. L'invention concerne également des méthodes de création d'une bibliothèque de spectres ; des méthodes de surveillance de l'efficacité d'un traitement photodynamique d'un tissu biologique ou de cellules in vivo, ainsi que des méthodes permettant d'améliorer l'efficacité d'un traitement photodynamique.

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