Bio-synthetic matrix and uses thereof

Details Bio-synthetic matrix and uses thereof Bio-synthetic matrix and uses thereof

C - Chemistry, Metallurgy

08

F

C08F 220/54 (2006.01) A61L 27/26 (2006.01) A61L 27/34 (2006.01) A61L 27/38 (2006.01) C08F 246/00 (2006.01)

Patent

CA 2495132

A bio-synthetic matrix comprising a hydrogel which is formed by cross-linking a synthetic polymer and a bio-polymer is provided. The matrix is robust, biocompatible and non-cytotoxic and is capable of supporting cell in-growth in vivo. The matrix can be tailored to further comprise one or more bioactive agents. The matrix may also comprise cells encapsulated and dispersed therein, which are capable of proliferating upon deposition of the matrix in vivo. Methods of preparing the bio-synthetic matrix and the use of the matrix in vivo for tissue engineering or drug delivery applications are also provided.

La présente invention concerne une matrice biosynthétique comprenant un hydrogel qui est formé par la réticulation d'un polymère synthétique et d'un biopolymère. La matrice est robuste, biocompatible, et non cytotoxique, elle permet d'assurer la croissance des cellules in vivo. La matrice peut être spécifiquement conçue pour comprendre également un ou plusieurs agents bioactifs. La matrice peut également comprendre des cellules encapsulées et dispersées dans cette dernière, qui sont capables de proliférer lors du dépôt de la matrice in vivo. Des méthodes de préparation de la matrice biosynthétique et d'utilisation de ladite matrice in vivo pour des applications de génie tissulaire et d'apport de médicament sont également présentées.

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