Bioabsorbable elastomeric polymer networks, cross-linkers...

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 77/12 (2006.01) A61K 6/087 (2006.01) A61L 27/18 (2006.01) A61L 27/58 (2006.01) C08J 3/24 (2006.01) C08K 5/20 (2006.01) C08L 75/02 (2006.01) C08L 75/04 (2006.01) C08L 77/06 (2006.01)

Patent

CA 2685965

The invention provides elastomeric polymer networks and semi-interpenetrating networks in which a linear PEA, PEUR or PEU polymer is crosslinked by ester or alpha- amino-acid containing cross-linkers that polymerize upon exposure to active species. Bioabsorbable elastomeric internal fixation devices fabricated using such polymer networks and semi-interpenetrating networks are useful for in vivo implant and delivery of a variety of different types of molecules in a time release fashion. Alpha-amino-acid containing ester amide cross-linkers are also provided by the invention.

L'invention propose des réseaux de polymère élastomère et des réseaux semi-interpénétration dans lesquels un polymère PEA, PEUR ou PEU linéaire est réticulé par un ester ou un acide aminé alpha contenant des agents de réticulation qui polymérisent lors de l'exposition à des espèces actives. Des dispositifs de fixation interne élastomères bioabsorbables fabriqués en utilisant de tels réseaux de polymère et de tels réseaux de semi-interpénétration sont utiles pour un implant in vivo et la distribution, d'une manière libérable dans le temps, d'une variété de types différents de molécules. Des agents de réticulation ester amide contenant un acide aminé alpha sont également proposés par l'invention.

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