Bioabsorbable polydepsipeptides, their preparation and use

Details Bioabsorbable polydepsipeptides, their preparation and use Bioabsorbable polydepsipeptides, their preparation and use

C - Chemistry, Metallurgy

07

K

530/11, 167/324

C07K 11/00 (2006.01) A61L 17/00 (2006.01) A61L 17/10 (2006.01) A61L 17/12 (2006.01) A61L 27/18 (2006.01) A61L 31/04 (2006.01) A61L 31/06 (2006.01) A61L 31/14 (2006.01) C07D 265/32 (2006.01) C08G 63/685 (2006.01) C08G 69/44 (2006.01)

Patent

CA 1338769

Disclosed are semi-crystalline depsipeptide polymers and copolymers particularly suitable for use in fabricating bioabsorbable medical implant devices such as sutures or clips and obtained through ring-opening polymerization of 3-substituted- 2,5-morpholinediones of the formula: Image (wherein R is alkyl, alkoxyalkyl, aryl, arylalkyl, alkylaryl, alkylarylalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, cyanoalkyl or aminocarbonylalkyl). The 3- substituted-2,5-morpholinediones are prepared by reacting a naturally occurring alpha-amino acid H2N-CH(R)-COOH with an alpha- halo acid chloride X-CH2CO-X in inert solvent in the presence of an acid acceptor.

586560

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