C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/103 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61K 49/08 (2006.01) A61K 49/14 (2006.01)
Patent
CA 2247620
The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
La présente invention se rapporte à des agents diagnostiques perfectionnés destinés à l'imagerie par résonance magnétique (IRM) et à l'imagerie optique. Elle se rapporte particulièrement à des agents pour IRM et imagerie optique qui permettent la détection sensible d'une bioactivité spécifique au sein d'un tissu. Ces agents sont des agents de contraste de type bioprécurseurs qui sont bioactivés in vivo en présence de la bioactivité spécifique. L'invention se rapporte en outre à des compositions pharmaceutiques contenant de tels agents et à des procédés d'utilisation de ces agents et des compositions contenant de tels agents.
Dumas Stephane
Dunham Stephen O.
Lauffer Randall B.
Mcmurry Thomas J.
Parmelee David J.
Epix Medical Inc.
Epix Pharmaceuticals Inc.
Smart & Biggar
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