Bioactive agent release coating with aromatic...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/26 (2006.01) A61L 29/04 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2490238

A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

L'invention concerne une composition de revêtement, ainsi qu'un procédé d'application d'une telle composition dans des conditions d'humidité contrôlée. Ladite composition est destinée à servir à recouvrir des surfaces de dispositifs afin d'en contrôler et/ou d'en améliorer le pouvoir de libération d'agents bioactifs dans des systèmes aqueux. La composition de revêtement peut être utilisée particulièrement avec des dispositifs médicaux qui subissent une flexion et/ou expansion importantes lors de leur apport et/ou utilisation, par exemple des extenseurs et des cathéters. La composition comporte l'agent bioactif en conjugaison avec une combinaison d'un premier composant polymère tel que polyaryl(méth)acrylate, polyaralkyl(méth)acrylate, ou polyaryloxyalkyl(méth)acrylate, et un second composant polymère tel que poly(éthylène-co-vinyl acétate).

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