Bioactive and/or targeted dendrimer conjugates

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 39/385 (2006.01) A61K 39/44 (2006.01) A61K 45/00 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01) C07K 14/525 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 14/555 (2006.01) C07K 17/06 (2006.01) C07K 17/08 (2006.01) C08G 73/00 (2006.01) C12N 5/10 (2006.01) C12N 15/02 (2006.01) C12N 15/09 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2161684

Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present, then the carried material may be a bioactive agent. Preferred dendritic polymers are dense starr polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.

On a préparé des conjugués polymères dendritiques qui se composent d'au moins un dendrimère associé à au moins une unité d'un produit transporté, le composé vecteur pouvant être un modificateur de réponse biologique. Le conjugué peut également comprendre un guide de ciblage, auquel cas le produit transporté peut être un agent bioactif. Les polymères dendritiques préférés sont des polymères en étoile denses, qui ont été complexés avec des modificateurs de réponse biologique. Ces conjugués et ces complexes présentent des propriétés particulièrement avantageuses dues à leurs caractéristiques tout à fait spéciales.

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