C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 11/10 (2006.01) A61K 47/48 (2006.01) A61L 15/28 (2006.01) A61L 15/40 (2006.01) A61L 26/00 (2006.01) C07K 17/08 (2006.01) C07K 17/10 (2006.01) C08B 15/06 (2006.01) C08B 37/12 (2006.01) C08F 8/30 (2006.01) C12N 11/08 (2006.01)
Patent
CA 2115630
ABSTRACT Polymers containing a plurality of free hydroxy groups, such as cellulose, agarose or polyvinyl alcohol, are contacted in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound, e.g. pyridine, pyrrole, pyridazine, their partially or fully hydrogenated analogs and any of these which may be substituted, in a pre-activation step prior to reaction with reactant for free hydroxy groups in the polymer, the polymer-bound residue of which reactant may be thereafter reacted in turn with amino compounds containing at least one unsubstituted N-attached hydrogen atom, e.g. proteins, thereby to form amine-polymer conjugates. The invention further relates to a powder, bandage, patch or like cover for application to wounds which has been manufactured from polymer containing a plurality of hydroxy groups by a process which includes the step of providing an amine conjugated to the polymer; the amine may be, e.g., trypsin, chymotrypsin, lysozyme, collagenase, albumin and hyaluronidase.
Margel Shlomo
Sturchak Sophia
Bar Ilan University
Robic
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