Bioactive fus1 peptides and nanoparticle-polypeptide complexes

Details Bioactive fus1 peptides and nanoparticle-polypeptide complexes Bioactive fus1 peptides and nanoparticle-polypeptide complexes

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 9/127 (2006.01) A61K 31/506 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 7/08 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2600370

A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.

La présente invention concerne un complexe de nanoparticule et de polypeptide contenant un polypeptide bioactif associé à une nanoparticule, le polypeptide bioactif étant modifié par l'addition d'un groupement chimique qui facilite l'absorption cellulaire de la protéine. Le polypeptide peut être une protéine ou un peptide. Dans certains modes de réalisation, la séquence d'acides aminés de la protéine ou du peptide est dérivée de la séquence d'acides aminés d'un produit génique suppresseur de tumeurs.

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