A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61M 36/14 (2006.01)
Patent
CA 2602090
The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.
La présente invention est basée sur la découverte qu~un stent vasculaire ou autre appareil médical implantable peut être enduit d~un polymère biocompatible biodégradable auquel est attaché un bioligand qui capture spécifiquement des progéniteurs des cellules endothéliales (PEC) dans le sang circulant pour favoriser la formation endogène d'endothelium sain chez les diabétiques de type II. Dans un mode de réalisation, le bioligand est un peptide qui se lie spécifiquement à un récepteur intégrine sur les PEC. L'invention concerne aussi des méthodes pour utiliser ces stents vasculaires et d~autres appareils implantables pour favoriser la guérison vasculaire chez les diabétiques de type II, par exemple après intervention mécanique.
Carpenter Kenneth W.
Defife Kristin M.
Grako Kathryn A.
Turnell William G.
Medivas Llc
Smart & Biggar
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