Bioactive stents for type ii diabetics and methods for use...

A - Human Necessities – 61 – L

Patent

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Details

A61L 31/10 (2006.01) A61F 2/82 (2006.01) A61K 9/00 (2006.01) A61L 31/12 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2562018

The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.

L'invention concerne une endoprothèse vasculaire ou un autre dispositif médical implantable susceptible d'être enveloppée d'un polymère biocompatible biodégradable auquel on fixe un ligand biologique qui capture spécifiquement des progéniteurs de cellules endothéliales (PEC) dans le sang en circulation afin de favoriser la formation endogène d'un endothélium sain dans le diabète type II. Dans un mode de réalisation, le ligand biologique est un peptide qui se lie spécifiquement à un récepteur des intégrines sur les PEC. L'invention concerne également des procédés permettant d'utiliser des endoprothèses vasculaires et d'autres dispositifs médicaux implantables pour favoriser la guérison vasculaire dans le diabète type II, par exemple à la suite d'une intervention mécanique.

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