A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) C07H 21/04 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2458443
Compositions and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a bioadhesive compound and a second population of carrier particles comprising a penetration enhancer. The bioadhesive extends the residence time of the drug and its absorptive potential across the portion of the intestinal mucosa made permeable by the penetration enhancer.
L'invention concerne des compositions et des procédés qui favorisent l'absorption des médicaments par les intestins. Cette formulation contient une première population de particules d'excipient renfermant un médicament et un composé bioadhésif, et une seconde population de particules d'excipient renfermant un activateur de pénétration. Ces compositions bioadhésives prolonge le temps de séjour du médicament ainsi que sa capacité d'absorption dans la partie de la muqueuse intestinale rendue perméable par l'activateur de pénétration.
Geary Richard S.
Hardee Gregory E.
Teng Ching-Leou
Tillman Lloyd G.
Weinbach Susan P.
Isis Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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