Bioadhesive compositions and methods of preparation and use

A - Human Necessities – 61 – L

Patent

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Details

A61L 24/00 (2006.01) A61L 24/10 (2006.01) A61L 27/22 (2006.01) A61L 31/04 (2006.01)

Patent

CA 2413337

The present invention relates generally to the preparation and use of novel enhanced biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen component in the presence of various critical biological and non-biological agents. The invention further relates to a novel method of using said enhanced fibrin sealant whereby the sealant and accompanying agent are delivered directly to a critical site within the body and sealed in place due to the biostatic quality of the sealant resulting in enhanced therapeutic value derived by the prolonged presence, and optionally time-released delivery, of said accompanying agent at the critical site.

D'une manière générale, l'invention concerne la préparation et l'utilisation de nouveaux adhésifs tissulaires améliorés qui consistent à combiner un fibrinogène et une thrombine. D'une manière plus spécifique, l'invention concerne une méthode de préparation d'un matériau d'obturation formé par reconstitution du composant fibrinogène en présence de plusieurs agents biologiques et non biologiques critiques. L'invention concerne également une nouvelle méthode d'utilisation dudit matériau d'obturation amélioré qui consiste à administrer ledit matériau d'obturation et l'agent associé directement sur un site critique à l'intérieur du corps et à les obturer directement sur place en raison de la qualité biostatique du matériau d'obturation qui améliore la valeur thérapeutique due à la présence prolongée, et éventuellement, à l'administration temporisée dudit agent associé sur le site critique.

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