Bioadhesive compositions and wound dressings containing them

Details Bioadhesive compositions and wound dressings containing them Bioadhesive compositions and wound dressings containing them

A - Human Necessities

61

L

A61L 15/58 (2006.01) A61B 5/0408 (2006.01) A61F 13/00 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61L 24/06 (2006.01) A61N 1/04 (2006.01)

Patent

CA 2338844

Water unstable bioadhesive compositions comprising an aqueous plasticiser, a cross-linking agent, a copolymer of a hydrophilic unsaturated water soluble first monomer and a hydrophilic unsaturated water-soluble second monomer, characterised in that they have: (i) a water activity of from 0.4 to 0.9; (ii) an elastic modulus at 1 rad/s of from 700 to 15,000 Pa; (iii) an elastic modulus at 100 rad/s of from 2000 to 40,000 Pa; (iv) a viscous modulus at 1 rad/s of from 400 to 14,000 Pa; (v) a viscous modulus at 100 rad/s of from 1000 to 35,000 Pa; wherein the viscous modulus is less than the elastic modulus in the frequency range of from 1 to 100 rad/s; and wound dressings containing them.

On décrit des compositions de bioadhésifs non stables à l'eau qui contiennent un plastifiant aqueux, un agent de réticulation, un copolymère d'un premier monomère soluble dans l'eau hydrophile non saturé et d'un deuxième monomère soluble dans l'eau, hydrophile non saturé. Ces compositions se caractérisent en ce qu'elles présentent: (i) une activité de l'eau comprise entre 0,4 et 0,9; (ii) un module d'élasticité à 1 rad/s compris entre 700 et 15 000 Pa; (iii) un module d'élasticité à 100 rad/s compris entre 2 000 et 40 000 Pa; (iv) un module de viscosité à 1 rad/s compris entre 400 et 14 000 Pa; (v) un module de viscosité à 100 rad/s compris entre 1 000 et 35 000 Pa. Le module de viscosité étant inférieur au module d'élasticité dans la plage de fréquence comprise entre 1 et 100 rad/s. L'invention porte sur les compositions ainsi que sur des pansements contenant ces dernières.

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