Bioadhesive extruded film for intra-oral drug delivery and...

Details Bioadhesive extruded film for intra-oral drug delivery and... Bioadhesive extruded film for intra-oral drug delivery and...

A - Human Necessities

61

K

167/159, 167/165

A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 9/70 (2006.01)

Patent

CA 1297408

ABSTRACT A bioadhesive extruded single or multi-layered thin film, especially useful in intra-oral controlled-releasing delivery, having a water soluble or swellable polymer matrix bioadhesive layer which can adhere to a wet mucous surface and which bioadhesive layer consists essentially of 40-95% by weight of a hydroxypropyl cellulose, 5-60% of a homopolymer of ethylene oxide, 0-10% of a water-insoluble polymer such as ethyl cellulose, propyl cellulose, polyethylene and polypropylene, and 2-10% of a plasticizer, said film having incorporated therein a medicament, e.g., anesthetics, analgesics, anticaries agents, anti-inflammatories, antihistamines, antibiotics, antibacterials, fungistats, etc.

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